Review-METABOLIC DISORDERS IN PATIENTS WITH HIV - ABSTRACT
Authors: Florentina Radu 1, Raluca Elena Jipa 1, Emilia Rusu 1, Raluca Cursaru 1, Ramona Dr?gu? 1, Daniela Stegaru 1, Andra Gabriela Gheorghi?? 1,2, Gabriela Radulian 1,2
1 „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 „Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania
Human Immunodeficiency Virus (HIV) infection and subsequent antiretroviral therapy (ART) are known to be related to different metabolic disorders. Although ART decreased HIV-associated mortality and morbidity, mortality rates in patients with HIV and ART are 3 to 15 higher than those in the general population. More than 50% of the mortality is due to diseases like: diabetes mellitus (DM), hypertension, cardiovascular diseases (CVD), chronic renal disease and complications following bone fractures. In patients with HIV the metabolic disorders are mainly caused by mithocondrial toxicity, a side effect of ART, and they are represented by: dyslipidemia, lipoatrophy, insulin resistance and diabetes mellitus.
Key words: insulin resistance, metabolic disorders, dyslipidemia, diabetes