Romanian  Journal of  Diabetes
Nutrition  and  Metabolic  Diseases

 
 

Original paper-THERAPEUTIC EFFECTS OF HYDROALCOHOLIC AND AQUEOUS EXTRACTS OF BERBERIS VULGARIS FRUITS IN STREPTOZOTOCIN INDUCED TYPE 1 DIABETES MELLITUS RATS - ABSTRACT

Authors: Masoumeh Karami 1, Masood Sepehrimanesh 2, Omid Koohi-Hosseinabadi 3, Mohammadreza Fattahi 1, Iman Razeghian Jahromi 4, Maral Mokhtari 5, Maryam Vasheghani Farahani 6
1 Department of Biochemistry, School of Medicine, AJA University of Medical Sciences, Tehran, Iran 2 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 3 Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran 4 Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 5 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran 6 Department of Forensic Medicine, AJA University of Medical Sciences, Tehran, Iran

Background and Aims: To evaluate and compare the beneficial effects of aqueous and hydroalcoholic extracts of Berberis vulgaris fruit in streptozotocin (STZ) induced type I diabetes mellitus (DM). Materials and Methods: Forty male rats were allocated into 4 groups as negative control (NC), positive control (PC), aqueous extract (AE), and hydroalcoholic extract (HE). DM was induced with streptozotocin (STZ) and three days later, the AE and HE groups received 200 mg/kg extracts orally for 30 days. The serum liver enzymes plus glucose level and concentration of HbA1c three days after STZ injection and at day 30 and liver histopathology at the end of the study were analyzed. Results: PC and both treatments groups had higher serum glucose levels in comparison to NC group (P<0.05). Higher serum alanine aminotransferase activities in both AE and HE groups in comparison to PC group (P=0.005 and P=0.045, respectively) and lower percentage of HbA1c in NC and HE groups in comparison to PC group (P=0.001 and P=0.014, respectively) were detected. Conclusion: Noticing the beneficial effects of B. vulgaris, the extract of this plant can be a good choice attenuating the side effects of DM. key words: Diabetes mellitus, Berberis vulgaris, aminotransferase, histopathology.

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